三毛流浪记

Chinese scientists develop electrode coating to address signal loss and tissue adhesion problems in long-term brain-computer interface implantation_我的网站

一 |     最初的、由社区制作的Ergo Clear是所谓的"Frankenswitch"，用户通过混合和匹配不同轴的组件来创造新的、有趣的打字感觉。

二 |     

    Photo: VCG
Chinese researchers have developed a multifunctional electrode coating that addresses key challenges in long-term brain-computer interface (BCI) implantation, including signal loss and tissue adhesion, bringing BCI one step closer to clinical application, the Global Times learned from the research team behind the findings on Sunday. 
As an emerging field combining neuroscience and artificial intelligence (AI), BCI faces a major challenge of ensuring long-term compatibility between electrodes and brain tissue. Previous clinical trials showed that immune responses could cause implanted electrodes to retract after just three months, severely reducing signal quality and the number of available channels. 
This problem stems from chronic inflammation triggered by implants, which creates insulating scar tissue around electrodes and separates them from neurons. Irreversible adhesion between electrodes and brain tissue after long-term implantation also makes device removal risky, potentially causing brain injury during follow-up surgeries.
Experiments showed that flexible neural electrodes coated with this material could operate stably in the brain for more than 300 days and could be safely removed without causing damage. This means the universal coating technology can make electrodes not only operate stably over the long term but can also be safely removed and replaced after aging, paving the way for long-term BCI applications.
Developed by the research team led by Zhang Wei at the Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, associated with Beijing Tiantan Hospital, Shanghai Institute of Microsystem and Information Technology and NeuroXess, a high-tech life science company specializing in BCI technologies, the cationic alternating peptide electrode coating preserves electrode flexibility and conductivity, while offering antibacterial, anti-protein adsorption and immune-rejection-inhibiting functions. 
A 300-day animal study showed the coating's effectiveness. Bare electrodes experienced a sharp loss of recording capability after 90 days of implantation and could barely detect neuronal signals after 300 days. In contrast, coated electrodes maintained stable recording channels and consistently captured neural signals above 155 microvolts. 
In terms of neural modulation, after 300 days of implantation, conventional electrodes required a current of 100 microamps to induce weak limb responses, while coated electrodes triggered clear movements with only 2 microamps, improving modulation efficiency by 50 times. 
Notably, the removal tests highlighted a key advantage of the coating that electrodes no longer form irreversible bonds with brain tissue. In the experiments, the coated electrodes were removed intact, with minimal damage to the surrounding brain tissue, Zhang told the Global Times on Sunday.
。最初的Ergo Clear模块将Cherry MX Clear的杆与Cherry MX Black轴的弹簧结合起来。这意味着它继承了MX Clear令人满意的回弹感受，但其弹簧又更轻，使其更容易按下。

三 | 正如专注于键盘的YouTuber Glarses在他去年对Ergo Clear改装的评论中指出的那样，后来改装者使用Cherry MX Blue、Brown或Red轴中的较轻弹簧，而不是GeekHack原帖中列出的MX Black弹簧，这种做法变得更加普遍。但无论哪种方式，其原理都是一样的--将更清晰的回弹与较轻的弹簧结合起来。这给启发了樱桃本周宣布的新品。在一份新闻稿中，该公司表示，生产官方版本的MX Ergo Clear轴将"使经验不足的用户不必手动改装它"。但是，作为一个官方轴产品，意味着新的Ergo Clear已经通过了Cherry的质量控制流程，这使它能够保证该轴将在5000万次的动作中继续存活而不会有任何打字感觉的损失。 该公司表示，它使用"高性能润滑脂"来润滑其官方版本的MX Ergo Clear，而不是原始型号中使用的PTFE润滑剂，这可以带来更"可靠的长期润滑"。

四 | 樱桃方面的发言人没有回答关于新的MX Ergo Clear轴中使用的弹簧的确切重量的具体问题，但它被列为40cN的驱动力（使一个键产生按压信号所需的力），以及55cN的操作力（推过触觉凸点所需的力）。作为参考，Cherry的MX茶轴的驱动力略高，为45cN，但操作力同样为55cN。先前存在的MX白轴有着更高的55cN驱动力和65cN的操作力。MX Ergo Clear轴的剖面图，显示其阀杆（中间的白色块）和弹簧尽管樱桃认为，提供官方的Ergo Clear轴将为用户省去自己动手的麻烦，但事实上，许多人已经通过购买许多第三方Ergo Clear风格的轴来避免这种麻烦，这些轴多年来为了满足需求而涌现出来。一个值得注意的早期模仿者是Zealio，它是由Cherry的竞争对手Gateron制造的。在Cherry的专利过期后，许多制造商现在都在生产基于Cherry的MX轴设计的轴。

五 | 通过其官方版本的MX Ergo Clear，Cherry似乎最终回应了人们对触觉轴的需求，到目前为止，这种轴只能通过DIY修改或竞争厂商获得。樱桃公司的新闻稿没有列出新轴的确切价格或发布日期，但指出它们将从"官方分销商"处获得，并直接内置到即将推出的现成键盘中。该轴将有RGB和非RGB两种类型，以及三针和五针版本。

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Published on:07:12:25